The synthesis of drug substances involves the use of reactive chemicals, reagents, solvents, catalysts, and other processing aids. As a result of chemical synthesis or subsequent degradation, impurities reside in all drug substances and associated veterinary medicinal products (VMPs).
EFSA Guidance on the establishment of the residue definition for dietary risk assessment provides directions for determining the metabolites that require hazard identification and characterisation using scientific tools and methods ((Q)SAR), read-across, threshold of toxicological concern (TTC)) and available data in combination, and for developing an appropriate testing strategy for these compounds.
Under Regulation (EC) 1223/2009 all cosmetic ingredients must be demonstrated that they do not pose any health concerns under normal conditions of use.
E-cigarettes are products that can be used for consumption of nicotine-containing vapour via a mouth piece. Solutions of e-cigarettes usually contain a mixture of propylene glycol (PG), which increases flavour, vegetable glycerin, which increases vapour, nicotine (≤ 20 mg/mL), and flavourings.
Dr. Lorenza Broccardo will be present at Eurotox in Ljubljana - Slovenia on 10-13 September 2023.
S-IN Soluzioni Informatiche Srl and JT International SA present poster P06-26: “Using the KNIME Analytics Platform for the analysis of different combination of evidence approaches with in silico toxicological predictions from VEGA and OECD (Q)SAR Toolbox”.
Come and visit us.
TOXIT is enthusiastic to join the 21st National Congress of Toxicology organised by the Italian society of Toxicology SITOX! We will be in Bologna from the 20th to the 22nd of February. We are also glad to share that Dr. Marta Lettieri will be presenting a poster titled “Skin sensitization: AOPs and (Q)SAR models” (P5/1).
Looking forward to meeting you there!
We are proud to announce that our colleague Marta Lettieri will be speaking at the workshop "Modelling & Simulation: Research Methodologies for Small Populations in Rare Diseases", which will be held in Bari on July 4th-5th.
