The synthesis of drug substances involves the use of reactive chemicals, reagents, solvents, catalysts, and other processing aids. As a result of chemical synthesis or subsequent degradation, impurities reside in all drug substances and associated veterinary medicinal products (VMPs).
EFSA Guidance on the establishment of the residue definition for dietary risk assessment provides directions for determining the metabolites that require hazard identification and characterisation using scientific tools and methods ((Q)SAR), read-across, threshold of toxicological concern (TTC)) and available data in combination, and for developing an appropriate testing strategy for these compounds.
Under Regulation (EC) 1223/2009 all cosmetic ingredients must be demonstrated that they do not pose any health concerns under normal conditions of use.
E-cigarettes are products that can be used for consumption of nicotine-containing vapour via a mouth piece. Solutions of e-cigarettes usually contain a mixture of propylene glycol (PG), which increases flavour, vegetable glycerin, which increases vapour, nicotine (≤ 20 mg/mL), and flavourings.
As partner of MN-AM, we are happy to announce new release of ChemTunes•ToxGPS® v2020: users will have full access to all the components i.e., the toxicity database, safety evaluation database, read-across/RAX workflows, in silico predictions, and Liver BioPath metabolizer.
Don’t miss the opportunity to meet the latest ACD/Labs developments by participating in Virtual French Symposium which will take place tomorrow, Tuesday 24 March 2020. https://lnkd.in/gmEgzKr Participation is free of charge but Registration is needed. The speeches and the success stories will illustrate how an intelligent management of analytical data can maximize its value, become a decision-making tool and support the R&D processes of the Industry The webinar will take place from 9:30 am to 16:45 CET. You can find full details of presentations in the Agenda https://lnkd.in/gjaz6UW If you need more information, don't hesitate to contact us at This email address is being protected from spambots. You need JavaScript enabled to view it.
A message from our colleague Simona:
