Under Regulation (EC) 1223/2009 all cosmetic ingredients must be demonstrated that they do not pose any health concerns under normal conditions of use. Thus, toxicological profiles of substances contained in the cosmetic product should be assessed.

The use of alternative methods for the assessment of toxicological profiles is supported, also, due to the ban of in vivo testing for the scope of cosmetics.

In this respect the Scientific Committee on Consumer Safety (SCCS) recommends that (Q)SAR methods, grouping and other chemical analogy approaches should be applied, whenever possible, to derive estimates on toxicity before any experimental testing is considered.

The committee also acknowledged that the use of a combination of different approaches in an in silico battery usually increases confidence of the derived predictions. Thus, in silico methodologies may be best used in a weight of evidence (WoE) approach.

TTC is also considered applicable, however based on the recommendations from SCCS should be based on internal doses.

Download this file (Cosmetic 1223-2009 Regulation.pdf)Cosmetic 1223-2009 Regulation.pdf[ ]3209 kB