Food additives are substances added to food to preserve flavour or enhance its taste, appearance, or other qualities. Regulation (EC) 1333/2008 sets the rules on food additives: definitions, conditions of use, labelling and procedures.
A tiered approach for their toxicological evaluation is proposed by EFSA. Before embarking on any testing, it is recommended to consider other relevant knowledge on the substance, including (Q)SAR data, structural alerts and read-across of data between structurally-related substances, which are considered as valid supporting information. This information can also be important for interpretation of genotoxicity testing results and particularly relevant for the choice of any in vivo study.
We can support you in the safety assessment of food additives with a range of solutions and services:
Non testing methods, such as (Q)SAR and read-across studies, can be pursued, being acceptable from a regulatory perspective.
We can support you in the safety assessment of FCMs with a range of solutions and services:
- Strategy definition for the hazard assessment of food additives
- Database search and expert review of experimental toxicological data
- TTC assessment
- Alert profiling
- Identification and assessment of toxicologically relevant alerts to understand toxicity mechanism and mode of action
- (Q)SAR predictions for genotoxicity and other relevant endpoints
- Read-across predictions