Read-across

Read-across is regarded as a technique for predicting endpoint information for one substance (target substance), by using data from the same endpoint from (an)other substance(s), (source substance(s)).

It is applicable to complex endpoints (e.g., repeated-dose, reproductive and developmental toxicity) and/or when experimental data on an endpoint of interest, for structurally related analogue(s), are available.

Read-across services

Analogue search

Search and assessment of potential analogue(s) for read-across, which includes: i) assessment of similarity toward the target compound (structural, mechanistic, phys-chem, ADME similarity); ii) collection and evaluation of analogue experimental data for the target endpoint(s).

Requisite for analogue(s) suitable for read-across

Read-across study

Read-across studies are performed following the current guidelines set by ECHA[1] and OECD[2], and documented according to the defined read-across reporting format. Critical scientific elements of the read-across approach are discussed to meet ECHA requirements for read-across assessment (i.e., Read-Across Assessment Framework)[3], and in line with the recent scientific literature.

Workflow for read across predictions

Endpoints

Toxicology

  • Skin irritation/corrosion
  • Eye irritation/corrosion
  • Skin senstisation (LLNA)
  • Mutagenicity
  • Clastogenicity
  • Carcinogenicity
  • Acute toxicity (oral, dermal, inhalation)
  • Repeated dose toxicity
  • Reproductive and developmental toxicity
  • Target organ toxicity

Ecotoxicology

  • Aquatic acute toxicity

Documentation

Read-across predictions are documented in a detailed report structured in accordance with regulatory requirements (ECHA-RAAF, OECD).

Reporting types:

  • STANDARD Reporting
    • Report compiled according to ECHA guideline
  • IUCLID Reporting
    • Report compiled according to ECHA guideline
    • IUCLID study record

[1] ECHA Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of Chemicals, available from http://echa.europa.eu/documents/10162/13632/information_requirements_r6_en.pdf
[2] OECD Joint meeting of the chemicals committee and the working party on chemical, pesticides and biotechnology, Guidance on grouping of chemicals, ENV/JM/MONO(2007)28.
[3] ECHA (2015) Read-Across Assessment Framework (RAAF).